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KMID : 1123920030170041097
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 4 p.1097 ~ p.1100
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Immunoregulatory Effects of Gungchihwadam-jeon and Cheongsinhwadam-jeon
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Kim Lak-Hyung
Kwon Jin
Lee Kwang-Gyu
Jeong Han-Sol
Oh Chan-Ho
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Abstract
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This study was performed to evaluate the immunoregulatory effects of Gungchihwadam-Jeon(궁치화담전, GCHDJ) and Cheongsinhwadam-Jeon(청신화담전, CSHDJ) was administered(p.o.) once a day for 14 days to mice. By the treatment of GCHDJ or CSHDJ was increased the cell viability of cultured mice splenocytes, thymocytes and mesenteric lymph node cells. Administration of GCHDJ or CSHDJ was increased the splenic T lymphocyte, especially the Tc cell subpopulation was increased by the GCHDJ, on the while the TH cell was increased by the CSHDJ. The administration of GCHDJ or CSHDJ was significantly increased the apoptosis of transplanted-L1210 leukemia cells to mice peritoneal cavity. These results suggest that GCHDJ and CSHDJ have an immunoregulatory action
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KEYWORD
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Gungchihwadam-Jeon(芎梔化痰煎), Cheongsinhwadam-Jeon(淸神化痰煎), splenocytes, thymocytes, mesenteric lymph node cells, L1210 leukemia cells, apoptosis
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